Chemokines and pain mechanisms
نویسندگان
چکیده
منابع مشابه
Chemokines and the pathophysiology of neuropathic pain.
Chemokines and chemokine receptors are widely expressed by cells of the immune and nervous systems. This review focuses on our current knowledge concerning the role of chemokines in the pathophysiology of chronic pain syndromes. Injury- or disease-induced changes in the expression of diverse chemokines and their receptors have been demonstrated in the neural and nonneural elements of pain pathw...
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1 Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, 412 E. Spokane Falls Boulevard, Spokane, WA 99204, USA 2Department of Medicine/Rheumatology, Case Western Reserve University, Cleveland, OH 44106, USA 3Veteran’s Administration, Ann Arbor, MI and Department of Internal Medicine/Rheumatology, University of Michigan, Ann Arbor, MI 48109, USA 4Department of D...
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Capsaicin, the active ingredient in hot chilli peppers, has selective actions on unmyelinated C-fibres and thinly myelinated A primary sensory neurones [37, 100] (Table 1). Most capsaicin-sensitive fibres are polymodal nociceptors which respond to a range of sensory stimuli including noxious pressure, heat and chemical irritants [51, 100], and are the most abundant class of nociceptive fibre. N...
متن کاملNeuropathic pain: mechanisms and treatments.
Neuropathic pain is caused by functional abnormalities of structural lesions in the peripheral or central nervous system, and occurs without peripheral nociceptor stimulation. Many common diseases, such as postherpetic neuralgia, trigeminal neuralgia, diabetic neuropathy, spinal cord injury, cancer, stroke, and degenerative neurological diseases may produce neuropathic pain. Recently, theories ...
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The purpose of this article is to summarise how functional imaging techniques have changed our understanding of normal and abnormal pain mechanisms, how they inform a change in clinical practice and to speculate on possible future clinical uses.
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ژورنال
عنوان ژورنال: Brain Research Reviews
سال: 2009
ISSN: 0165-0173
DOI: 10.1016/j.brainresrev.2008.12.002